Chinese design gel that heals wounds in the arteries and the heart

Dominican Republic.- Under the title Hemostatic Hydrogel strongly adhesive for the repair of arterial and cardiac hemorrhages, the scientific journal Nature published on Tuesday the discovery of a group of Chinese scientists.

It is an adhesive gel that is activated with ultraviolet light and that in tests carried out in pigs it was verified that it is able to quickly heal lesions in arteries and in the heart.

In fact, in the future, its application in surgical procedures could be habitual, summarized Nature.

The expert Hongwei Ouyang and a group of colleagues from the University of Zhejiang, in Hangzhou (China), demonstrated the applications of this bio-gel after carrying out several tests with pigs, although they warned that more studies are still necessary in order to confirm that his employment is safe.

The British scientific journal indicates in its latest issue that uncontrollable bleeding after suffering a trauma or surgery is one of the main causes of death and it is difficult to heal those wounds without using stitches.

In the case of gel solutions, these require solid adhesion to the wet tissue and the strength to withstand high blood pressures and movement of the heartbeat.

Nature recalls that there are very few non-toxic materials that meet these requirements.

According to the publication, Ouyang’s team of experts designed a gel that mimics the composition of the so-called extracellular matrix, a network of proteins that is rapidly strengthened when exposed to ultraviolet light.

In preliminary experiments undertaken in the laboratory with animal models, the scientists showed that their system was capable of sealing wounds in pig livers.

After these first tests, they practiced a series of surgical procedures in pigs and proved that wounds in the heart could be sealed using the hydrogel created, without having to resort to stitches.

After performing these procedures, the experts followed three of the pigs operated on during a two-week recovery period and did not detect any abnormalities as a result of their surgery.

“Existing hemostatic agents poorly control the bleeding of traumatic arterial and cardiac injuries due to their weak adhesion to wet and mobile tissues. Here we designed a photoreactive adhesive that mimics the composition of the extracellular matrix (ECM), “says his study in its justification.

The hydrogel based on biomacromolecules underwent rapid gelification and fixation to adhere and seal arteries and bleeding cardiac walls after irradiation with UV light.

The repairs endured a blood pressure of up to 290 mm Hg, “significantly higher than blood pressure in most clinical settings” (systolic blood pressure 60-160 mm Hg), plus.

“the most important thing is that This hydrogel can stop high-pressure bleeding of the carotid arteries of pig with incision wounds of 4 ~ 5 mm in length and of pig hearts with cardiac penetration holes of 6 mm in diameter “, it is detailed.

The repair of aortic rupture and bleeding from the heart derived from cardiac penetration wounds are difficult surgical challenges. Currently, surgical suture is the only clinical method for aortic rupture and sealing of the heart wound.

However, this is not feasible outside the surgical units and is not attempted in most emergency situations.

“With the recent progress in materials science, many experimental chemical agents have been tested for rapid wound sealing, such as fibrin glue, gelatin, collagen, oxidized cellulose, zeolites, peptides, polymers.

And hydrogels, “but” none of these materials is adequate for haemostasis and the sealing of aortic and cardiac traumas due to its slow haemostatic performance, poor wet tissue surface adhesion, and weak or inflexible binding mechanisms “, insists in the study.

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